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KMID : 0362919830010010085
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Journal of the Korean Society for Therapeutic Radiology and Oncology
1983 Volume.1 No. 1 p.85 ~ p.94
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The Radiotherapy Result of the Nasopharyngeal Carcinoma
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Park Charn-Il
Koh Kyoung-Hwan
Kim Chong-Sun
Kim Noe-Kyeong
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Abstract
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A total of 47 patients with a diagnosis of nasopharyngeal carcinoma was treated in Department of Therapeutic Radiology, Seoul National University Hospital during last 4 years.
Of the 47 patients, 23(49%) had undifferentiated carcinoma, 20(43%) had squamous cell carcinoma, while 4(8%) had lymphoepithelioma. Most of the patients(71%) has Stage Ⅳ disease, cervical lymph node metastases were found in 36(77%) and distant metastasis was found in 1 at the time of diagnosis.
Complete response rate after radiotherapy for 47 patients of nasopharyngeal carcinoma was 85.1%. The overall actuarial 3 year survival rates was 0.718 and the disease free actuarial 3 year survival rates was 0.468. Nodal involvement and symptom duration were statistically significiant influencing factors for actuarial survival rate.
Treatment failures were found in 20 patients (42.6%), local recurrence only in 6(30%), local and neck recurrence in 3(15%), local recurrence with metastasis in 4(20%) and distant metastasis only in 7(35%). Local failures were more frequent in the patients with cranial nerve symptoms (P=0.032). Distant metastases were more frequent with T4 lesions (P=0.047), and with nodal involvement (P<0.01).
Retreatment after the tumor recurrence was chemotherapy and/or radiotherapy, two patients refreated for local recurrence were alive without evidence of disease for more than 19 and 44 months after retreatment.
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